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Potential mechanisms of resistance to venetoclax and strategies to circumvent it

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Venetoclax (ABT-199), a first-in-class orally bioavailable BCL-2-selective inhibitor, was recently approved by the FDA for use in patients with 17p-deleted chronic lymphocytic leukemia who have received prior therapy. It is also being evaluated in numerous clinical trials for treating patients with various hematologic malignancies. | Potential mechanisms of resistance to venetoclax and strategies to circumvent it

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