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Genotoxicity studies of arsenic, lead and their interaction in Wistar rats

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The present study was carried out on sixty Wistar rats divided into groups I, II, III, IV and V for a period of 28 days to study genotoxic effects induced by arsenic, lead and their mixture. The group I served as control while group II, III and IV were gavaged with sodium arsenite, lead acetate and mixture of both metals, respectively. The group V served as positive control which was treated with cyclophosphamide. Chromosomal aberration assay and micronuclei assay was studied from bone marrow cells of femur bone of all the rats. Arsenic and lead alone was equally genotoxic to that of mixture of both metals while their genotoxic potential was less than cyclophosphamide. | Genotoxicity studies of arsenic lead and their interaction in Wistar rats