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Synthesis and biological evaluation of new quinazolinone derivatives

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The paper presents a simple and efficient synthesis of a series of new quinazolinone derivatives 8a-h. First, the reaction of 5-hydroxyanthranilic acid (6) with acetic anhydride at 160–180oC for 2 h gave the intermediate 7 in high yield. This intermediate was then reacted with amines in acetic acid at 180 oC for 14 h afforded new quinazolinone derivatives 8a-h in 77–92%. Synthesized compounds were structurally confirmed using spectroscopic methods: 1H, 13CNMR and mass spectrum. |

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Synthesis and biological evaluation of new quinazolinone derivatives

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