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Study on determination of nifedipine in dog plasma by ultra performance liquid chromatography with tandem mass spectrometric detection

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To validate the determination method of nifedipine (NIF) in dog plasma by ultra performance liquid chromatography with tandem mass spectrometric detection (UPLC-MS/MS). The evaluation of the specificity, selectivity, lower limit of quantitation, accuracy, precision, calibration curve and the linear range, recovery, carry-over, matrix effect, stability of NIF in plasma following the guidance of US-FDA. |

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