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Human pancreatic cancer stem cells are sensitive to dual inhibition of IGF-IR and ErbB receptors

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Pancreatic ductal adenocarcinoma is a particularly challenging malignancy characterized by poor responsiveness to conventional chemotherapy. Although this tumor frequently overexpresses or possesses constitutively activated variants of IGF-IR and EGFR/Her-2, clinical trials using inhibitors of these receptors have failed. |

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Treatment with a combination of the ErbB (HER) family blocker afatinib and the IGF-IR inhibitor, NVP-AEW541 induces synergistic growth inhibition of human pancreatic cancer cells

The Warburg effect in human pancreatic cancer cells triggers cachexia in athymic mice carrying the cancer cells
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