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Optimisation of an immunohistochemistry method for the determination of androgen receptor expression levels in circulating tumour cells

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AZD3514 inhibits and down regulates the androgen receptor (AR) and has undergone clinical trials in prostate cancer. To provide proof-of-mechanism (POM) in patients, an immunohistochemistry (IHC) method for determination of AR in circulating tumour cells (CTC) was developed and validated. |

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