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Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86

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The RET tyrosine kinase receptor has emerged as a target in thyroid and endocrine resistant breast cancer. We previously reported the synthesis of kinase inhibitors with potent activity against RET. Herein, we have further investigated the effect of the lead compound SPP86 on RET mediated signaling and proliferation. |

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Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86
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