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TH17/TH1 role in endocrine disorders among chronic HCV infected patients

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Since its discovery in 1989, hepatitis C virus (HCV) infection has become a major cause of chronic liver disease worldwide with 14.7% prevalence in Egypt. There is increasing body of evidence that chronic HCV infection is usually associated with several extrahepatic manifestations. Several studies have shed light on the association of autoimmune thyroiditis (ATD) and type 1 diabetes (T1D) with chronic HCV infection as both are considered to be one of the most common organ specific autoimmune disease frequently occur together. IL17 secreting helper T (Th17) and classic Th1 cells have been heavily implicated in mediating autoimmune endocrine diseases. |