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A cytotoxic stilbenoid and 4-hydroxycinnamates from stemona cochinchinensis plants, growing in savannakhet province, lao PDR

Four non-alkaloidal metabolites: Stemanthrene C, methyl ferulate, methyl 4-hydroxycinnamate and B-sitosterol were isolated from the roots of Stemona cochinchinensis plants which were collected in Savannakhet Province (Laos). Their structures were elucidated by spectroscopic analyses. Stemanthrene C exhibited medium cytotoxic activity against the KB cell line with an IC50 value of 82.03 ug mL−1. | JOURNAL OF SCIENCE OF HNUE Chemical and Biological Sci. 2012 Vol. 57 No. 8 pp. 9-15 This paper is available online at http stdb.hnue.edu.vn A CYTOTOXIC STILBENOID AND 4-HYDROXYCINNAMATES FROM Stemona cochinchinensis PLANTS GROWING IN SAVANNAKHET PROVINCE LAO PDR Vonganatha Khamko1 2 Dang Ngoc Quang1 and Pham Huu Dien1 1 Faculty of Chemistry Hanoi National University of Education 2 Faculty of Chemistry Savannakhet University Savannakhet Province Lao PDR Abstract. Four non-alkaloidal metabolites stemanthrene C methyl ferulate methyl 4-hydroxycinnamate and β-sitosterol were isolated from the roots of Stemona cochinchinensis plants which were collected in Savannakhet Province Laos . Their structures were elucidated by spectroscopic analyses. Stemanthrene C exhibited medium cytotoxic activity against the KB cell line with an IC50 value of 82.03 µg mL 1 . Keywords Stemona cochinchinensis stemanthrene C methyl 4-hydroxycinnamate methyl ferulate cytotoxic activity. 1. Introduction Various species of the genus Stemona Stemonaceae are widely used in Vietnam Laos and other countries of Southeast Asia as an anti-cough remedy and for their antiparasitic properties. Specifically extracts made from the tuberous roots of S.tuberosa Lour. S.saxorum Gagnep. and S.cochinchinensis have been used in Vietnamese and Laotian traditional medicine in a broad range of applications including relief of cough and asthma and reduction of enteric helminths and ectoparasites in humans and cattle 1-4 . Chemical investigations of Stemona genus species have resulted in the isolation of more than 90 different alkaloids most of which share the common pyrrolo 1 2-a azepine basic nucleus a minor fraction also containing the pyrido 1 2-a azepine skeleton 5-7 . However ofthe non-alkaloid components of this genus less than 20 compounds mostly of the dihydrophenanthrenes and dihydrostibenes have been investigated 8 9 . Herein Received May 25 2012. Accepted October 1 2012. Chemistry Subject Classification .