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Abstract dissertation Dr. Chemistr: Isolation, chemical modification and biological evaluation of steroids from the starfish Acanthaster planci

Study on chemical composition of starfish Acanthaster planci of Vietnam, synthesizing hydroxyl and oxime derivatives from a steroid isolated from this starfish and assessing biological activity of isolated and synthesized compounds. | MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCES AND TECHNOLOGY ----------------------------- DINH THI HA ISOLATION CHEMICAL MODIFICATION AND BIOLOGICAL EVALUATION OF STEROIDS FROM THE STARFISH ACANTHASTER PLANCI Speciality Natural Products Chemistry Code 9 44 01 07 ABSTRACT DISSERTATION Dr. CHEMISTRY HANOI-2020 This dissertation was completed in Graduate university of Sciences and Technology Vietnam Academy of Science and Technology. Supervisor 1 Assoc. Prof. Tran Thi Thu Thuy Supervisor 2 Assoc. Prof. Ngo Dai Quang Reviewer 1 Reviewer 2 Reviewer 3 The thesis will be defended in front of the Academy Thesis Evaluation Council at the Graduate university of Sciences and Technology Vietnam Academy of Science and Technology. At the time. hour . August 2020 Thesis can be found at the - Library of Graduate university of Sciences and Technology - Vietnam National Library INTRODUCTION 1. Reason to choose the topic Vietnam has extremely diverse and abundant marine resources with hundreds of thousands of different species of plants animals and microorganisms. However the values provided for medicinal resources of marine species is still very limited. Nowaday there have been many steroid subtances isolated from marine organisms and evaluated for biological activity. In particular many polar steroid compounds exhibit biological activity against many cancer cell lines and can be applied in medicine and pharmacy. These steroids are important to organic synthesis. They have become a model to synthesize from popular natural steroids by more efficient and economical methods. The starfish class belong to the echinoderm phylum which is one of the rich sources provide of polarizing steroid compounds. This substance class has diverse structure and they exhibit many biological activities such as antibacterial antifungal anti-inflammatory anti-cancer anti-viral inhibiting fertilization. So polar steroids from starfish have been