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Inhibition of calcium oxalate crystallization causing kidney stones in vitro by an extract of Bluméa balsamifera

The inhibitory effect of Bluméa balsamifera extract on the nucleation, growth, and aggregation phases of calcium oxalate formation has been studied. Plant samples were extracted by the maceration method with 80.00% ethanol. The results showed that the moisture content of Bluméa balsamifera extract was 82.83% and the yield was 5.79%. Bluméa balsamifera extract contains bioactive compounds including alkaloids, flavonoids, saponins, terpenoids, tannins, and phenol. | DALAT UNIVERSITY JOURNAL OF SCIENCE Volume 11 Issue 1 2021 3-13 INHIBITION OF CALCIUM OXALATE CRYSTALLIZATION CAUSING KIDNEY STONES IN VITRO BY AN EXTRACT OF Bluméa balsamifera Nguyen Pham Tuana Bang Hong Lamc Nguyen Pham Tua Le Thao Nguyenb Tran Duc Taib a An Giang Biotechnology Center An Giang Vietnam b Gachon University Seongnam Gyeonggi South Korea c An Giang University An Giang Vietnam Corresponding author Email ngphamtuan1983@gmail.com Article history Received April 4th 2020 Received in revised form September 28th 2020 Accepted October 26th 2020 Available online February 5th 2021 Abstract The inhibitory effect of Bluméa balsamifera extract on the nucleation growth and aggregation phases of calcium oxalate formation has been studied. Plant samples were extracted by the maceration method with 80.00 ethanol. The results showed that the moisture content of Bluméa balsamifera extract was 82.83 and the yield was 5.79 . Bluméa balsamifera extract contains bioactive compounds including alkaloids flavonoids saponins terpenoids tannins and phenol. Bluméa balsamifera extract has the ability to inhibit the nucleation of calcium oxalate with an IC50 value of 4.25 mg ml. Bluméa balsamifera extract has a significant inhibitory effect on the growth of calcium oxalate crystals with an IC50 value of 2.99 mg ml. Finally Bluméa balsamifera extract is capable of inhibiting the aggregation of calcium oxalate with an IC50 value of 2.56 mg ml. Keywords Aggregation Bluméa balsamifera Calcium oxalate Growth Nucleation. DOI http dx.doi.org 10.37569 DalatUniversity.12.1.691 2022 Article type peer-reviewed Full-length research article Copyright 2021 The author s . Licensing This article is licensed under a CC BY-NC 4.0 3 DALAT UNIVERSITY JOURNAL OF SCIENCE NATURAL SCIENCES AND TECHNOLOGY 1. INTRODUCTION Kidney stones are hard solid crystals formed in the kidney. The stones have five forms calcium oxalate calcium phosphate or a mixture of both crystals accounting for 85 of monolithic and