Synthesis, in vitro acetylcholinesterase inhibitory activity evaluation and docking investigation of some aromatic chalcones

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Synthesis, in vitro acetylcholinesterase inhibitory activity evaluation and docking investigation of some aromatic chalcones

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In this study, a total of twenty chalcones were synthesized via Claisen-Schmidt condensation reaction and evaluated for their in vitro acetylcholinesterase inhibitory activities using Ellman’s method. Molecular docking studies on acetylcholinesterase were performed to elucidate the interactions between these chalcone derivatives and acetylcholinesterase active site at the molecular level. From the series, six compounds (S1-5 and S17) exhibited strong acetylcholinesterase inhibitory activities with IC50 values below 100 µM compared to the parent unsubstituted chalcone. |

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Synthesis, in vitro acetylcholinesterase inhibitory activity evaluation and docking investigation of some aromatic chalcones

Synthesis, in vitro acetylcholinesterase inhibitory activity evaluation and docking investigation of some aromatic chalcones

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Đang chuẩn bị liên kết để tải về tài liệu: Synthesis, in vitro acetylcholinesterase inhibitory activity evaluation and docking investigation of some aromatic chalcones

Synthesis, in vitro acetylcholinesterase inhibitory activity evaluation and docking investigation of some aromatic chalcones

Design, synthesis and biological evaluation of 1,3,4-oxadiazoles/thiadiazoles bearing pyrazole scaffold as antimicrobial and antioxidant candidates

New quinazolinone derivatives: Synthesis and in vitro cytotoxic activity

Enhanced collagen type I synthesis by human tenocytes subjected to periodic in vitro mechanical stimulation

Assessment of the antioxidant power of in vitro obtained coleus forskohlii briq

Effect of morphology and (Sn, Cr) doping on in vitro antiproliferation properties of hydrothermally synthesized 1D GaOOH nanostructures

Design, synthesis, and in vitro antitumor activity of 6-aryloxyl substituted quinazoline derivatives

Microwave assisted one-pot catalyst free green synthesis of new methyl-7-amino-4-oxo-5-phenyl-2- thioxo-2,3,4,5-tetrahydro-1H-pyrano[2,3-d] pyrimidine-6-carboxylates as potent in vitro antibacterial and antifungal activity

Synthesis and characterization of Schiff base analogues of fluoroaniline and their antibiocidal activity against MRSA

Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives

Đang chuẩn bị liên kết để tải về tài liệu:
Synthesis, in vitro acetylcholinesterase inhibitory activity evaluation and docking investigation of some aromatic chalcones