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Molecular profile of KRAS G12C-mutant colorectal and non-small-cell lung cancer

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KRAS is the most frequently mutated oncogene in cancer, however efforts to develop targeted therapies have been largely unsuccessful. Recently, two small-molecule inhibitors, AMG 510 and MRTX849, have shown promising activity in KRAS G12C-mutant solid tumors. |

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Molecular profile of KRAS G12C-mutant colorectal and non-small-cell lung cancer

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