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Pulmonary vasodilation by sildenafl in acute intermediate-high risk pulmonary embolism: A randomized explorative trial

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To investigate if acute pulmonary vasodilation by sildenafl improves right ventricular function in patients with acute intermediate-high risk pulmonary embolism (PE). Methods: Single center, explorative trial. Patients with PE were randomized to a single oral dose of sildenafl 50 mg (n=10) or placebo (n=10) as add-on to conventional therapy. The time from hospital admission to study inclusion was 2.3±0.7 days. |