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Efficacy, safety, and tolerability of combined pirfenidone and N-acetylcysteine therapy: A systematic review and metaanalysis

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While antifibrotic drugs significantly decrease lung function decline in idiopathic pulmonary fibrosis (IPF), there is still an unmet need to halt disease progression. Antioxidative therapy with N-acetylcysteine (NAC) is considered a potential additional therapy that can be combined with antifibrotics in some patients in clinical practice. |

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