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Summary of medical doctoral thesis: Research on establishing an autism model using sodium valproate and ameliorative effects of enriched environment on behaviors in white mice

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This research with two aims: Establishing an animal model of autism using Swiss white mice by prenatal exposure to sodium valproate. Evaluating the effects of enriched environment on behaviors in modelled white mice | MINISTRY OF MINISTRY OF DEFENCE EDUCATION AND TRAINING VIETNAM MILITARY MEDICAL UNIVERSITY DAO THU HONG RESEARCH ON ESTABLISHING AN AUTISM MODEL USING SODIUM VALPROATE AND AMELIORATIVE EFFECTS OF ENRICHED ENVIRONMENT ON BEHAVIORS IN WHITE MICE Speciality Physiology Code 62720107 SUMMARY OF MEDICAL DOCTORAL THESIS HANOI - 2018 This research was carried out in Vietnam Military Medical University Supervisors 1. Tran Hai Anh M.D. Ph.D. Assoc.Prof. 2. Can Van Mao M.D. Ph.D. Assoc.Prof. Reviewer 1 Reviewer 2 Reviewer 3 This thesis will be defended in doctoral examination council of Vietnam Military Medical University at .on the date of . This thesis is available at 1. National Library 2. Library of Vietnam Military Medical University 3. . 1 INTRODUCTION 1. Imperativeness Autism is a neurodevelopmental disorder whose diagnosis is based on three behavioral criteria unusual reciprocal social interactions deficits in communication and stereotyped repetitive behaviors with restricted interests. The etiology and pathophysiology of autism are unclear. Nowadays autism is known as a modern-day phenomenon with the prevalence increase all over the world. The studies of CDC shown that the prevalence of autism was 0.5 per 1000 children in 1985 increased 12 per 1000 children in 2012. Prenatal exposure to valproate VPA leads abnormal neurodevelopment and increased risk of autism spectrum disorders. In animal model prenatal VPA-exposure also lead abnormal behaviors and pathology similar to that observed in autism individuals. For that reason valproate is used to induce animal model of autism in order to investigate the mechanism of biological changes and to evaluate the effect of interventions for autism. In Vietnam there are several researches about some risk factors some clinical features in autistic patients. However there is no research about animal model of autism and pathophysiological mechanism for autism. So we conducted this research with two aims 1. Establishing an animal .

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