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The medical doctoral thesis: Study on histopathological fearures, immunohistochemistry and methylation of rassf1a gene in prostate cancer

Do the following: Study on some histopathological features of prostate carcinoma at Military Hospital 103 according to the 2004 WHO classification. Determine the expression of some immunological markers and methylation status of the RASSF1A gene and compare with some histopathological features in prostate carcinoma. | MINISTRY OF EDUCATION MINISTRY OF AND TRAINING NATIONAL DEFENSE MILITARY MEDICAL UNIVERSITY VI THUAT THANG STUDY ON HISTOPATHOLOGICAL FEARURES IMMUNOHISTOCHEMISTRY AND METHYLATION OF RASSF1A GENE IN PROSTATE CANCER Speciality Biomedical Sciences Code 9720101 THE MEDICAL DOCTORAL THESIS Ha Noi 2018WORKS ARE COMPLETED AT MILITARY MEDICAL UNIVERSITY Name of supervisors 1. Prof. Dr. Nguyen Dinh Tao MD. Ph.D 2. Dr. Nguyen Ngoc Hung MD. Reviewer 1 Assoc. Prof. Nguyen Van Hung MD. Ph.D. Reviewer 2 Assoc. Prof. Quan Hoang Lam MD. Ph.D. Reviewer 3 Assoc. Prof. Trinh Tuan Dung MD. Ph.D. The thesis will be protected before the Board of thesis dissertation on the day A thesis can be found at 1. National Library 2. Library of the Military Medical University 3 INTRODUCTION TO THESIS 1. Set the problem Prostate cancer Pca is common in men over age of 65 the disease is occult. Most cases were detected accidentally by histopathological examination. In Vietnam the standard age rate in 2012 was 3.4 100000 people and queued the 10 th in cancer in men. Pca can be treated effectively if the disease is detected early. Therefore the finding of early detection methods accurate diagnosis proper assessment of histopathological lesions by a standard and a uniform classification is essential to the development of therapeutic approaches and prognosis of this disease. Several studies have shown that the RASSF1A gene methylation occurs at an early stage in the formation and progression of the Pca. Thus RASSF1A gene methylation marker is being considered to Pca. In Vietnam studies on DNA methylation in cancer have been carried out lately histopathological and immunohistochemistry studies of Pca according to the 2004 World Health Organization WHO classification of tumors of the prostate are lacking. Based on that we do the following a. Study on some histopathological features of prostate carcinoma at Military Hospital 103 according to the 2004 WHO classification. b. Determine the expression of .