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Summary of Biotechnology doctoral thesis: Evaluation of changes in proliferation and cytoskeletal structure of human umbilical cord mesenchymal stem cells under simulated microgravity

The aim of this thesis was to gain an understanding of how the simulated microgravity condition affects the development of hucMSC by investigating the changes in cell morphology, proliferation and cytoskeleton structure of hucMSCs under in vitro condition. | MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY - Hồ Nguyễn Quỳnh Chi EVALUATION OF CHANGES IN PROLIFERATION AND CYTOSKELETAL STRUCTURE OF HUMAN UMBILICAL CORD MESENCHYMAL STEM CELLS UNDER SIMULATED MICROGRAVITY Major Biotechnology Code 9 42 02 01 SUMMARY OF BIOTECHNOLOGY DOCTORAL THESIS Ho Chi Minh 2021 The thesis was carried out at Graduate University of Science and Technology - Vietnam Academy of Science and Technology Supervisor Prof. Hoàng Nghĩa Sơn Reviewer 1 Reviewer 2 Reviewer 3 . The thesis will be defended to the Academy-level doctoral thesis committee at Graduate University of Science and Technology - Vietnam Academy of Science and Technology at 2021. The thesis can be found at - Library of Graduate University of Science and Technology - National Library of Vietnam 1 INTRODUCTION 1. Rationale In gravitational biology studies of microgravity in space have shown many effects of gravity conditions on biological processes gravity-sensitive mechanisms or the gravity-based orientation of organisms. However research in space has encountered a number of difficulties including expensive research facilities and negative effects of microgravity on astronauts. To overcome the above difficulties scientists have developed biological system models that simulate conditions similar to the microgravity in space for further gravitational studies on living organisms. Many studies showed that cells in different organisms behave differently in space than they do on Earth. Due to the great diversity of cell types in nature the effects of microgravity on those cells are extremely diverse and often complex. Some studies on the role of microgravity in cell proliferation and differentiation have demonstrated that cells that grow in microgravity develop differently than under normal conditions leading to notable changes in cell division. Cytoskeleton is also one of the most affected structure under .