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TetR-family transcription factors in Gramnegative bacteria: Conservation, variation and implications for efflux-mediated antimicrobial resistance

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TetR-family transcriptional regulators (TFTRs) are DNA binding factors that regulate gene expression in bacteria. Well-studied TFTRs, such as AcrR, which regulates efflux pump expression, are usually encoded alongside target operons. Recently, it has emerged that there are many TFTRs which act as global multi-target regulators. |