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Direct measurement of pervasive weak repression by microRNAs and their role at the network level

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A gene regulatory network (GRN) comprises many weak links that are often regulated by microRNAs. Since miRNAs rarely repress their target genes by more than 30%, doubts have been expressed about the biological relevance of such weak effects. These doubts raise the possibility of under-estimation as miRNA repression is usually estimated indirectly from equilibrium expression levels. |

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Direct measurement of pervasive weak repression by microRNAs and their role at the network level
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