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Chemical composition, and antibacterial and antioxidant activities of essential oils from Laggera tomentosa Sch. Bip. ex Oliv. et Hiern (Asteraceae)

Laggera tomentosa Sch. Bip. ex Oliv. et Hiern (Asteraceae), an endemic Ethiopian medicinal plant, is traditionally used to treat various ailments. Previously, the chemical constituents of the essential oil (EO) of its leaves and inflorescence were documented. However, no data about the chemical compositions of other parts of the EOs of the plant have been reported to date. Moreover, there are no previous biological activity reports on any parts of the EOs of this plant. Thus, in this study, the EOs were isolated from the stem bark and roots of this plant by hydrodistillation and analyzed using gas chromatography-mass spectrometry to identify their components. In addition, antibacterial potentials of the oils were evaluated using the disc diffusion and minimal inhibitory concentration (MIC) methods. | Turkish Journal of Chemistry Turk J Chem 2020 44 1539-1548 http journals.tubitak.gov.tr chem TÜBİTAK Research Article doi 10.3906 kim-2004-50 Chemical composition and antibacterial and antioxidant activities of essential oils from Laggera tomentosa Sch. Bip. ex Oliv. et Hiern Asteraceae 1 1 2 1 3 Tokuma GETAHUN Vinit SHARMA Deepak KUMAR Neeraj GUPTA 1 Advance School of Chemical Sciences Shoolini University Bajhol HP India 2 School of Pharmacy Faculty of Pharmaceutical Sciences Shoolini University Bajhol HP India 3 Department of Chemistry and Chemical Sciences Central University of Himachal Pradesh Kangra HP India Received 17.04.2020 Accepted Published Online 24.08.2020 Final Version 16.12.2020 Abstract Laggera tomentosa Sch. Bip. ex Oliv. et Hiern Asteraceae an endemic Ethiopian medicinal plant is traditionally used to treat various ailments. Previously the chemical constituents of the essential oil EO of its leaves and inflorescence were documented. However no data about the chemical compositions of other parts of the EOs of the plant have been reported to date. Moreover there are no previous biological activity reports on any parts of the EOs of this plant. Thus in this study the EOs were isolated from the stem bark and roots of this plant by hydrodistillation and analyzed using gas chromatography-mass spectrometry to identify their components. In addition antibacterial potentials of the oils were evaluated using the disc diffusion and minimal inhibitory concentration MIC methods. 2 2-diphenyl-1-picrylhydrazyl DPPH and hydrogen peroxide methods were also employed to assess their antioxidant properties. Oxygenated monoterpenes 71.82 and 77.51 of which 2 5-dimethoxy-p-cymene 57.28 and 64.76 and thymol methyl ether 9.51 and 8.93 were identified as major components in the EOs of stem bark and roots of L. tomentosa and the oils were the most potent in the DPPH IC50 0.33 1.10 and 0.39 0.97 mg mL assay respectively. Moreover the EOs demonstrated appreciable activity .