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The prognostic and clinical significance of IFI44L aberrant downregulation in patients with oral squamous cell carcinoma

It is a basic task in high-throughput gene expression profiling studies to identify differentially expressed genes (DEGs) between two phenotypes. RankComp, an algorithm, could analyze the highly stable withinsample relative expression orderings (REOs) of gene pairs in a particular type of human normal tissue that are widely reversed in the cancer condition, thereby detecting DEGs for individual disease samples measured by a particular platform. | Ou and Wu BMC Cancer 2021 21 1327 https doi.org 10.1186 s12885-021-09058-y RESEARCH Open Access The prognostic and clinical significance of IFI44L aberrant downregulation in patients with oral squamous cell carcinoma Deming Ou1 and Ying Wu2 Abstract Background It is a basic task in high-throughput gene expression profiling studies to identify differentially expressed genes DEGs between two phenotypes. RankComp an algorithm could analyze the highly stable within- sample relative expression orderings REOs of gene pairs in a particular type of human normal tissue that are widely reversed in the cancer condition thereby detecting DEGs for individual disease samples measured by a particular platform. Methods In the present study Gene Expression Omnibus GEO Series GSE GSE75540 GSE138206 were down- loaded from GEO by analyzing DEGs in oral squamous cell carcinoma based on online datasets using the RankComp algorithm using the Kaplan-Meier survival analysis and Cox regression analysis to survival analysis Gene Set Enrich- ment Analysis GSEA to explore the potential molecular mechanisms underlying. Results We identified 6 reverse gene pairs with stable REOs. All the 12 genes in these 6 reverse gene pairs have been reported to be associated with cancers. Notably lower Interferon Induced Protein 44 Like IFI44L expression was asso- ciated with poorer overall survival OS and Disease-free survival DFS in oral squamous cell carcinoma patients and IFI44L expression showed satisfactory predictive efficiency by receiver operating characteristic ROC curve. Moreover low IFI44L expression was identified as risk factors for oral squamous cell carcinoma patients OS. IFI44L downregula- tion would lead to the activation of the FRS-mediated FGFR1 FGFR3 and downstream signaling pathways and might play a role in the PI3K-FGFR cascades. Conclusions Collectively we identified 6 reverse gene pairs with stable REOs in oral squamous cell carcinoma which might serve as gene signatures playing a .