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The impact of young age (

The role of young age ( | Bouferraa et al. BMC Cancer 2022 22 27 https doi.org 10.1186 s12885-021-09100-z RESEARCH Open Access The impact of young age Bouferraa et al. BMC Cancer 2022 22 27 Page 2 of 12 Keywords Breast cancer Disease-free survival Overall survival Oncology Age Background survival disadvantage in younger patients with some Breast cancer is the most common type of cancer going further and reporting better survival outcomes in worldwide with an incidence of around 2.3 million the younger patient population 8 10 16 . cases in 2020 1 . It also accounts by itself for 15.5 As such and in order to better understand the role of of cancer-related mortalities in females alone 1 . A age at diagnosis on the outcome of patients with breast similar epidemiologic profile is reported in Lebanon cancer in our population we conducted a prospective where breast cancer accounts for around one third of study at a tertiary care and referral center in Lebanon all reported cancer cases in females 2 3 . While most involving Lebanese women recently diagnosed with non- breast cancer cases occur in older women the world- metastatic breast cancer. We assessed the difference in wide incidence of the disease in the younger popula- 10- years survival outcomes between female patients with tion has been on the rise in the past decade 4 . This localized breast cancer aged below or above 40 years at is especially the case in Lebanon where around 20 of diagnosis. We also studied the impact of several prognos- the breast cancer cases occur in females younger than tic factors including molecular markers genetic markers 40 years old 5 . In particular breast cancer in Lebanese and histopathologic markers on the survival outcomes female patients presents at a median age of 50 years and the interaction of those variables with age. more than 10 years earlier than their female counter- parts in the western countries where the median age at Methods presentation approaches 63 years 6 . This increase in Study design and