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Metalign: Efficient alignment-based metagenomic profiling via containment min hash

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Metagenomic profiling, predicting the presence and relative abundances of microbes in a sample, is a critical first step in microbiome analysis. Alignment-based approaches are often considered accurate yet computationally infeasible. Here, we present a novel method, Metalign, that performs efficient and accurate alignmentbased metagenomic profiling. |