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Long-term outcome and relapse patterns in Ewing sarcoma patients with extensive lung/ pleural metastases after a complete response to systemic therapy

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Ewing sarcoma (ES) is sensitive to systemic therapy, including chemotherapy and anti-angiogenesis Tyrosine Kinase Inhibitors(aaTKIs). However, the prognosis of patients with metastatic disease remains poor. Recurrence or distant metastasis after a complete response (CR) or near-CR due to systemic therapy is not rare. |