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Highly Selective and Sensitive Dual Channel New Schiff base Chemosensor based on 5-bromo-2-hydroxybenzaldehyde and its Co(II), Ni(II), Cu(II) and Zn(II) Complexes - Synthesis, Spectral and Theoretical characterization and Pharmacological applications

In recent times many research activities have been carried out to prove the metal ion detection ability of Schiff bases. [13,14] In the present study, a new Schiff base has been synthesized from 5-bromo-2- hydroxybenzaldehyde and naphthalene-1,8-diamine and it is complexated with Co(II), Ni(II), Cu(II) and Zn(II) ions. The biological application of all the compounds has been analyzed and metal ions recognition property of the Schiff base has also been studied. | Cite this paper Vietnam J. Chem. 2023 61 4 429-444 Research article DOI 10.1002 vjch.202200150 Highly Selective and Sensitive Dual Channel New Schiff base Chemosensor based on 5-bromo-2-hydroxybenzaldehyde and its Co II Ni II Cu II and Zn II Complexes - Synthesis Spectral and Theoretical characterization and Pharmacological applications Sambamoorthy Santhi1 Rajalingam Renganathan2 Subbiah Amala1 Gobalakrishnan Suganya1 Karikalan Abinaya1 1 PG and Research Department of Chemistry Seethalakshmi Ramaswami College Tiruchirappalli 620 002 Tamil Nadu India 2 School of Chemistry Bharathidasan University Tiruchirappalli 620 024 India Submitted August 14 2022 Revised November 7 2022 Accepted May 3 2023 Abstract A new Schiff base N N -Bis 5-Bromosalicylidine -1 8-diaminonaphthalene BBSDN and its Co II Ni II Cu II and Zn II complexes were synthesized. All the compounds were characterized by various spectral studies IR UV 1H NMR 13C NMR and EI-Mass and DFT calculations. Conductance measurements magnetic study and metal estimation studies were performed for the complexes to establish the structure. Thermal studies were done to account for the coordination of water molecules. Redox property of the synthesized complexes was established by Cyclic Voltammetry studies. Synthesized compounds were screened against fungal and bacterial pathogens and in most of the cases the complexes were found to be more active than the Schiff base. MIC value for copper and zinc complexes against the fungal pathogen Candida albicans are determined as 25 ppm and 10 ppm respectively. Metal ion pertinency of the Schiff base was investigated by absorption and fluorescence methods and was found to be highly selective and sensitive for the detection of Cu II ion. Mode of interaction has been proved through 1H NMR titrations and the interaction is explained as due to CHEQ mechanism. Stability constant of the complex formed during the detection process was determined by Benesi-Hildebrand plot. Detection .