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Nanogel systems based on heparin and pluronics for redox-responsive delivery of poorly water-soluble drugs in cancer treatment

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This study aimed to design a nanocarrier system for the efficient delivery of poorly soluble drugs in cancer treatment. Nanogel systems were prepared from copolymers of Heparin and different Pluronics, in which the Hep-Plu conjugates were formed via disulfide bridges of cystamine molecules. The obtained Hep-Plu systems were proved and characterized using specific techniques including H-NMR, zeta potential, DLS and FT-IR. |