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Báo cáo khoa học: "Distribution of trkA in cerebral cortex and diencephalon of the mongolian gerbil after birth"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Distribution of trkA in cerebral cortex and diencephalon of the mongolian gerbil after birth | J. Vet. Sci. 2004 5 4 303-307 JOURNAL OF Veterinary Science Distribution of trkA in cerebral cortex and diencephalon of the mongolian gerbil after birth Il-Kwon Park1 Xilin Hou2 Kyung-Youl Lee2 O-sung Park2 Kang-Yi Lee3 Min-young Kim1 Tae-sun Min4 Geun-jwa Lee5 Won-sik Kim6 Moo-kang Kim2 Angio Lab Inc. Daejeon 302-735 Korea College of Veterinary Medicine Chungnam National University Daejeon 305-764 Korea College of Oriental Medicine Daejeon University Daejeon 302-716 Korea 4Department of Life Science KOSEF Daejeon 305-350 Korea 5Chungnam Livestock Veterinary Service Institute Gongju 314-140 Korea 6Department of Anatomy College of Medicine Chungnam National University Daejeon 301-130 Korea TrkA is essential components of the high-affinity NGF receptor necessary to mediate biological effects of the neurotrophins NGF. Here we report on the expression of trkA in the cerebral cortex and diencephalon of mongolian gerbils during postnatal development. The expression of trkA was identified by immunohistochemical method. In parietal cortex and piriform cortex higher levels of trkA-IR immunoreactivity were detected at 3 days postnatal P3 and at P9. Although trkA was not expressed till P3 in the parietal cortex it was detectable at birth in the piriform cortex. Several regions such as Layers I IV VI did not show much expression. Layer I showed especially weak labeling. In the hippocampus thalamus and hypothalamus higher levels of trkA-IR were detected at P6 and P12 than earlier days. But trkA was not expressed at birth in the hippocampus at P3 in the reticular thalamic nucleus or neonatally in the dorsomedial hypothalamic nucleus. This data shows that expression of trkA is developmentally regulated and suggests that high affinity neurotrophin-receptors mediate a transient response to neurotrophines in the cerebral cortex and diencephalon during mongolian gerbil brain ontogeny. Key words trkA NGF mongolian gerbil cerebral cortex diencephalon Corresponding author Tel .