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Báo cáo khoa học: " Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Pharmacokinetics and dosage regimen of ceftriaxone in E. coli lipopolysaccharide induced fever in buffalo calves | J. Vet. Sci. 2005 6 2 147-150 JOURNAL OF Veterinary Science Pharmacokinetics and dosage regimen of ceftriaxone in E. coll lipopolysaccharide induced fever in buffalo calves Manmohan Singh Dardi Suresh Kumar Sharma1 Anil Kumar Srivastava2 Department of Pharmacology and Toxicology College of Veterinary Sciences Punjab Agricultural University Ludhiana-141004 India faculty of Veterinary and Animal Husbandry Sher-e-Kashmir University Agricultural Science Technology R.S. Pura Jammu-181102 India The present study was planned to investigate the pharmacokinetics of ceftriaxone in experimentally induced febrile buffalo calves n 5 . The fever was induced by intravenous injection of E.coli lipopolysaccaride 1 pg kg . To study the pharmacokinetics ceftriaxone was administered at the dose rate of 10 mg kg body wt. in all animals. At 1 min the peak concentration of ceftriaxone was 79.4 2.37 pg ml and the drug was detected up to 6 h. The elimination rate constant was 0.35 0.02 h and elimination half-life was 2.04 0.14 h. The apparent volume of distribution Vd re and total body clearance ClB were 1.21 0.15 l kg and 0.41 0.03 l kg h respectively. To maintain a minimum therapeutic concentration of 1 pg kg a satisfactory dosage regimen of cefriaxone in febrile buffalo calves is 19 mg kg followed by 18 mg kg at 8 h intervals. Key words buffalo calf ceftriaxone dosage regimen febrile pharmacokinetics. Introduction Ceftriaxone is a third-generation semi synthetic bactericidal cephalosporin which is effective against a wide variety of Gram-positive and Gram-negative microorganisms. The dosage regimen of antibiotics determined in healthy subjects can not be extrapolated to diseased conditions because the disease conditions are reported to markedly alter the pharmacokinetics of several antimicrobial agents 5 9 11 16 17 20 . Fever which is one of the most common manifestation of many infectious diseases 8 is reported to induce a series of biochemical and physiological alterations in cells 10