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Báo cáo khoa học: " Pharmacokinetics and bioavailability of doxycycline in ostriches (Struthio camelus) at two different dose rates"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Pharmacokinetics and bioavailability of doxycycline in ostriches (Struthio camelus) at two different dose rates | J. Vet. Set. 2006 7 4 327-332 JOURNAL OF Veterinary Science Pharmacokinetics and bioavailability of doxycycline in ostriches Struthio camelus at two different dose rates Ehab A. Abu-Basha1 Nasir M. Idkaidek2 Tareq M. Hantash1 department of Basic Veterinary Medical Sciences Faculty of Veterinary Medicine anddepartment of Pharmaceutical Technology Faculty of Pharmacy Jordan University of Science and Technology Irbid 22110 Jordan A bioavailability and pharmacokinetics study of doxycycline was carried out on 30 healthy ostriches after a single intravenous IV intramuscular IM and oral dose of 15 mg kg body weight. The plasma doxycycline concentration was determined by HPLC UV at 0 pretreatment 0.08 0.25 0.5 1 2 4 6 8 12 24 and 48 h after administration. The plasma concentration-time curves were examined using non-compartmental methods based on the statistical moment theory for only the higher dose. After IV administration the elimination half-life t1 2p mean residence time MRT volume of distribution at the steady-state Vss volume of distribution Vdarea and total body clearance C1B were 7.67 0.62 h 6.68 0.86 h 0.86 0.161 kg 1.67 0.521 kg and 2.51 0.63 ml min kg respectively. After IM and oral dosing the mean peak plasma concentrations Cmax were 1.34 0.33 and 0.30 0.04 pg ml respectively which were achieved at a postadministration time tlll x of 0.75 0.18 3.03 0.48 h respectively. The t1Z2p Vdarea and CIb after IM administration were 25.02 3.98 b 23.99 3.41 kg and 12.14 1.71 ml min kg respectively and 19.25 2.53 h 61.49 7 l kg and 40.19 3.79 ml min kg after oral administration respectively. The absolute bioavailability F of doxycycline was 5.03 and 17.52 after oral and IM administration respectively. These results show that the dose data from other animals particularly mammals cannot be extrapolated to ostriches. Therefore based on these results along with those reported in the literature further studies on the pharmacokinetic pharmacodynamic in vitro minimum inhibitory .