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Báo cáo khoa học: "Targeted surveillance to assess the presence of BSE in the age risk population of cattle slaughtered in Bursa, Turkey: preliminary results of an immunohistochemical detection study for the 2004-2005 period"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Targeted surveillance to assess the presence of BSE in the age risk population of cattle slaughtered in Bursa, Turkey: preliminary results of an immunohistochemical detection study for the 2004-2005 period | J. Vet. Set. 2007 8 2 193-195 JOURNAL OF Short Communication Veterinary Science Targeted surveillance to assess the presence of BSE in the age risk population of cattle slaughtered in Bursa Turkey preliminary results of an immunohistochemical detection study for the 2004-2005 period MMiifif Enhromon1 1VT rrTiiiiT íVyvoĩẾ A 11 in At AVlm l RnlAnf TT rli y TIahi z IVficivlirwrlul T2iit ca1 IVLUlll tvaill Ỉ41ỈỈMỈỈ -LV-1- vzZililll vzZijjill 1Ỉ.1IIỈỈVL ayiyIyvV .ulilvlll EJvlIlZ. J.T-U.3U vJUl isvl Aylin Alasonyalilar1 Rahsan Yilmaz1 1 Pathology Department Faculty of Veterinary Medicine and 2Biostatistics Department Faculty of Medicine Uludag University Gorukle Campus 16059 Gorukle Bursa Turkey Bovine spongiform encephalopathy BSE a member of the transmissible spongiform encepahlopathies has been a notifiable disease in Turkey since 1997. In 2002 the BSE status of Turkey was assessed by the EU Scientific Steering Committee as it is likely but not confirmed .This study presents the results of a targeted surveillance study to assess the presence of BSE in the age risk population of Bursa Turkey. In the assessment procedure the immunohistochemical detection of protease-resistant prion protein PrP-Sc was aimed at and applied to 420 brain tissues of cattle slaughtered in Bursa at an age of 30-months and older. None of the samples were positive for BSE. Key words active surveillance age risk BSE immunohistochemistry Turkey Bovine spongiform encephalopathy BSE in cattle is a neurodegenerative disorder belonging to the transmissible spongiform encepahlopathies TSE a group of diseases that include sheep scrapie and human Creutzfeldt-Jacob disease CJD 8 . The accumulation of abnormal isofonns of the host encoded cellular prion protein PrP-C as a protease-resistant prion protein PrP-Sc in the nervous tissue has been proposed as the cause of the TSEs 6 . TSE s are characterized by long asymptomatic incubation periods 9 . The pathognomonic lesion is a combination of both spongiform