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Báo cáo khoa học: "Effectiveness of 99mTc-tetrofosmin for assessment of heart functions in micropigs"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Effectiveness of 99mTc-tetrofosmin for assessment of heart functions in micropigs | J. Vet. Set. 2007 8 3 223-227 JOURNAL OF Veterinary Science Effectiveness of mTc-tetrofosmin for assessment of heart functions in micropigs 1 r -XT T 1 - TT T It TT n 1 I T - TT 1 TT T T 1 TT T r l l T T Min Young Lee Sang Hun Lee Jae Hong Park Jung Sun Heo Yu Jin Lee Han Na Suh Jung Jun Min Young Soon Seo2 Ho Jae Han1 1 College of Veterinary Medicine Biotherapy Human Resources Center Chonnam National University Gwangju 500-757 Korea department of Nuclear Medicine Chonnam National University Hwasun Hospital Hwasun 519-809 Korea This study examined the suitability of a nuclear imaging technique using mTc-tetrofosmin as an agent to assess the heart functions of healthy micropigs. The mean age of the pigs was 360 days male and the mean body weight was 353 kg ranging from 34.5-36 kg. There were no significant perfusion defects in any of the reconstructed images. Gated single-photon emission computed tomography imaging can be used to calculate the ventricular volume and ejection fraction EF . In this case an EF of 79 was calculated from the ventricular volume of the end-systolic image 10 ml subtracted from that of the end-diastolic volume 49 ml . A perfusion defect particularly the apex lateral wall is unlikely because of the presence of a preserved wall motion in a segment with a defect. It is concluded that quantitative cardiac scintigraphy using mTc-tetrofosmin is an adequate technique for estimating the heart functions of healthy micropigs. Key words ejection fraction EF heart function micropig mTc-tetrofosmin Introduction Transplantation is the preferred treatment for chronic failure of the heart kidneys lungs and liver. However transplantation has a fairly limited impact on medical practice due to the lack of organs. It has been estimated that 10 of the organs needed each year in the United States become available and that the percentage is continuing to decline 3 . Hence there is increasing interest in the possibility of using animals as a source of organs and .