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Báo cáo y học: "Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects"

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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects. | Int. J. Med. Sci. 2004 1 181-192 181 Research paper Received 2004.6.25 Accepted 2004.9.20 Published 2004.10.12 Abstract Key words Author biography Corresponding address International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2004 1 3 181-192 2004 Ivyspring International Publisher. All rights reserved Elevated plasma homocysteine is positively associated with age independent of C677T mutation of the methylenetetrahydrofolate reductase gene in selected Egyptian subjects Mohamed El-Sammak1 Mona Kandil 1 Safaa El-Hifni1 Randa Hosni2 Mahmoud Ragab1 1 Departments of Chemical Pathology Medical Research Institute Hospital Alexandria University Egypt. 2 Internal Medicine Cardiology Unit Medical Research Institute Hospital Alexandria University Egypt. This study aimed to evaluate the plasma homocysteine tHcy and folate levels as well as the methylenetetrahydrofolate reductase MTHFR C677T mutation in Egyptian subjects. Fasting total homocysteine tHcy and the MTHFR C677T mutation were evaluated in 50 healthy young control males age 35-50 years Gp1 50 elderly males age ranged between 50-75 years without any cardiovascular diseases Gp2 and 50 age matched elderly male patients Gp3 with myocardial infarction. There was a significant elevation of plasma tHcy in the patients group and Gp2 compared to the young control group Gp1 . The total plasma homocysteine tHcy in the control group Gp2 and the patients group were 17.99 9.76 39.9 20.06 and 43.8 13.13 pmol L respectively. The frequency of the TT genotype was 12 in the patient group compared with 8 in the young healthy controls and elderly subjects Gp2 . The CT genotype constituted 36 48 and 44 in the control group Gp2 and the patients group respectively. There was no significant difference in the occurrence of the TT genotype between the studied groups. Plasma tHcy correlated positively with age total cholesterol urea creatinine glucose levels and carotid intimal thickness CIT . Conclusion The MTHFR mutation does .

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