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Báo cáo y học: "Management of HCV Infection and Liver Transplantation"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Management of HCV Infection and Liver Transplantation. | Int. J. Med. Sci. 2006 3 79 Review International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3 2 79-83 2006 Ivyspring International Publisher. All rights reserved Management of HCV Infection and Liver Transplantation Thomas D. Schiano and Paul Martin Adult Liver Transplantation Recanati Miller Transplantation Institute Division of Liver Diseases Department of Medicine The Mount Sinai School of Medicine New York NY USA Corresponding address Thomas D. Schiano M.D. The Division of Liver Diseases Recanati-Miller Transplantation Institute Box 1104 The Mount Sinai Medical Center One Gustave Levy Place New York New York 10029. Phone 212 241-1424 212 2411598. Fax 212 241-2138. Email thomas.schiano@mountsinai.org paul.martin@mountsinai.org Received 2005.12.30 Accepted 2006.03.01 Published 2006.04.01 A major challenge facing liver transplant recipients and their physicians is recurrence of hepatitis C virus infection following otherwise technically successful liver transplantation. Recurrent infection leads to diminished graft and patient survival. Although a number or predictors of severe recurrence have been identified no definitive strategy has been developed to prevent recurrence. Generally the tempo of hepatitis C recurrence is gauged by serial liver biopsies with the decision to intervene with antiviral therapy based on local philosophy and expertise. Treating hepatitis C in this population has a number of major challenges including diminished patient tolerance for side-effects as well as managing the patient s immunesuppression. However sustained viral responses are possible with the potential to reduce the impact of recurrent hepatitis on the graft. However recurrent hepatitis C virus infection will remain the most frequent form of recurrent disease in liver transplant programs for the foreseeable future. Key words recurrent hepatitis C liver transplantation antiviral therapy 1. Treatment of HCV in the Liver Transplant Population Currently there .