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Báo cáo y học: " Eradication rate of Helicobacter pylori according to genotypes of CYP2C19, IL-1B, and TNF"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Eradication rate of Helicobacter pylori according to genotypes of CYP2C19, IL-1B, and TNF. | Int. J. Med. Sci. 2006 3 135 Research Paper International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3 4 135-140 2006 Ivyspring International Publisher. All rights reserved Eradication rate of Helicobacter pylori according to genotypes of CYP2C19 IL-1B and TNF-A Yoshiko Ishida Yasuyuki Goto Takaaki Kondo Mio Kurata Kazuko Nishio Sayo Kawai Tomo Osafune Mariko Naito Nobuyuki Hamajima Department of Preventive Medicine Biostatistics and Medical Decision Making Nagoya University Graduate School of Medicine Nagoya 466-8550 Japan Correspondence to Yasuyuki Goto M.D. Ph.D. Department of Preventive Medicine Biostatistics and Medical Decision Making Nagoya University Graduate School of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550 Japan TEL 81-52-744-2132 FAX 81-52-744-2971 e-mail y-goto@med.nagoya-u.ac.jp Received 2006.08.01 Accepted 2006.09.10 Published 2006.09.10 Background Lansoprazole amoxicillin and clarithromycin are commonly used drugs for eradication of Helicobacter pylori H. pylori . A few studies reported that the eradication rate was influenced by the functional polymorphism of CYP2C19 whose product metabolizes proton pomp inhibitors including lansoprazole. Methods This study examined the eradication rate among 67 participants in the polymorphism study who visited Daiko Medical Center Nagoya University from July 2004 to October 2005. The participants aged 20 to 69 years were classified into three group according to CYP2C19 genotype rapid metabolizers rM with 1 1 genotype intermediate metabolizers IM with 1 2 or 1 3 genotype and poor metabolizers pm with 2 2 2 3 or 3 3 genotype. For the genotype classification G681A 681G for 1 and 681A for 2 and G636A 636G for 1 and 636A for 3 were genotyped by PCR with confronting two-pair primers PCR-CTPP . They were also genotyped for IL-1B T-31C and1 TNF-A T-1031C by a duplex pCR-CtPp. Results The eradication rate was 70.0 for RM 93.9 for IM and 85.7 for PM. The difference in the rate between RM and IM