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Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis. | Int. J. Med. Sci. 2007 4 59 International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2007 4 2 59-71 Ivyspring International Publisher. All rights reserved Review Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk A meta-analysis Chikako Kiyohara1 and Kouichi Yoshimasu2 1. Department of Preventive Medicine Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan. 2. Department of Hygiene School of Medicine Wakayama Medical University 811-1 Kimiidera Wakayama 641-8509 Japan Correspondence to Chikako Kiyohara PhD Department of Preventive Medicine Graduate School of Medical Sciences Kyushu University 3-1-1 Maidashi Higashi-ku Fukuoka 812-8582 Japan. Tel 81 92 642 6113 Fax 81 92 642 6115 e-mail chi-kako@phealth.med.kyushu-u.ac.jp Received 2006.12.04 Accepted 2007.01.30 Published 2007.02.01 Various DNA alterations can be caused by exposure to environmental and endogenous carcinogens. Most of these alterations if not repaired can result in genetic instability mutagenesis and cell death. DNA repair mechanisms are important for maintaining DNA integrity and preventing carcinogenesis. Recent lung cancer studies have focused on identifying the effects of single nucleotide polymorphisms SNPs in candidate genes among which DNA repair genes are increasingly being studied. Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. We identified a sufficient number of epidemiologic studies on lung cancer to conduct a meta-analysis for genetic polymorphisms in nucleotide excision repair pathway genes focusing on xeroderma pigmentosum group A XPA excision repair cross complementing group 1 eRCC1 ERCC2 XPD ERCC4 xPf and ERCC5 XPG. We found an increased risk of lung cancer among subjects carrying the ERCC2 751Gln Gln genotype odds ratio OR 1.30 95 confidence interval CI 1.14 - 1.49 . We found a protective effect of