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Báo cáo y học: "A pilot study of rizatriptan and visually-induced motion sickness in migraineu"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: A pilot study of rizatriptan and visually-induced motion sickness in migraineurs. | Int. J. Med. Sci. 2009 6 212 International Journal of Medical Sciences 2009 6 4 212-217 Ivyspring International Publisher. All rights reserved Research Paper A pilot study of rizatriptan and visually-induced motion sickness in mi-graineurs Joseph M. Furman1 H Dawn A. Marcus2 1. Department of Otolaryngology University of Pittsburgh School of Medicine Pittsburgh USA 2. Department of Anesthesiology Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh USA ISI Correspondence to Joseph M. Furman Suite 500 Eye Ear Institute 203 Lothrop Street Pittsburgh PA 15213. Phone 412-647-2117 Fax 412-647-2080 Email furman@pitt.edu Received 2009.05.14 Accepted 2009.08.04 Published 2009.08.06 Abstract Background Limited evidence suggests that rizatriptan given before vestibular stimulation reduces motion sickness in persons with migraine-related dizziness. The present study was designed to test whether rizatriptan is also effective in protecting against visually-induced motion sickness and to test whether rizatriptan blocks the augmentation of motion sickness by head pain. Material and Methods Using randomized double-blind placebo-controlled methodology 10 females 6 with migrainous vertigo V and four without vertigo V- received 10 mg rizatriptan or placebo two hours prior to being stimulated by optokinetic stripes. Visual stimulation was coupled with three pain conditions no pain N thermally-induced hand pain H and temple pain T . Motion sickness and subjective discomfort were measured. Results Motion sickness was less after pre-treatment with rizatriptan for 4 of 10 subjects and more for 5 of 10 subjects. Augmentation of motion sickness by head pain was seen in 6 of 10 subjects this effect was blunted by rizatriptan in 4 of these 6 subjects. Subjective discomfort was significantly more noticeable in V subjects as compared with V- subjects. Conclusions These pilot data suggest that rizatriptan does not consistently reduce visually-induced motion sickness in .