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Báo cáo y học: " Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approac"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Factors affecting the long-term response to tacrolimus in renal transplant patients: Pharmacokinetic and pharmacogenetic approach. | Int. J. Med. Sci. 2010 7 94 International Journal of Medical Sciences 2010 7 2 94-100 Ivyspring International Publisher. All rights reserved Research Paper Factors affecting the long-term response to tacrolimus in renal transplant patients Pharmacokinetic and pharmacogenetic approach Paraskevi F. Katsakiori1 Eirini P. Papapetrou2 George C. Sakellaropoulos3 Dimitrios S. Goumenos4 George C. Nikiforidis3 Christodoulos S. Flordellis1 1. Department of Pharmacology School of Medicine University of Patras Rion Greece 2. Center for Cell Engineering Molecular Pharmacology and Chemistry Program Memorial Sloan-Kettering Cancer Center MSKCC New York NY 10065 USA 3. Department of Medical Physics School of Medicine University of Patras Rion Greece 4. Department of Internal Medicine-Nephrology School of Medicine University of Patras Rion Greece H Corresponding author Paraskevi F. Katsakiori Department of Pharmacology School of Medicine University of Patras 26500 Rion Greece Tel 30 6937 438208 Email vkatsak@med.upatras.gr vkatsak@yahoo.com Received 2010.04.20 Accepted 2010.05.10 Published 2010.05.11 Abstract Background The aim of our study was to determine the impact of CYP3A5 1 and CYP3A5 3 on the kinetics of tacrolimus in renal transplant recipients. Material and methods Forty kidney recipients were selected to participate. Maintenance scheme consisted of tacrolimus a purine inhibitor and a steroid. CYP3A5 genotyping was performed with PCR and RFLP. Pharmacokinetic model was developed with Linear Regression and General Linear Model repeated measures approach. The impact of sex CYP3A5 1 allele age at transplantation hepatic and renal function on tacrolimus kinetics was examined. Results The frequency of CYP3A5 3 3 and CYP3A5 1 3 genotype was 35 40 and 5 40 respectively. No CYP3A5 1 1 was detected. CYP3A5 1 variant was associated with significant lower TAC dose adjusted concentration at 3 6 12 and 36 months after transplantation. Hepatic and renal function showed a significant .