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Báo cáo y học: "omparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Comparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study. | Int. J. Med. Sci. 2010 7 366 International Journal of Medical Sciences 2010 7 6 366-377 Ivyspring International Publisher. All rights reserved Research Paper Comparative Efficacy and Tolerability of 5-Loxin and Aflapin Against Osteoarthritis of the Knee A Double Blind Randomized Placebo Controlled Clinical Study Krishanu Sengupta1 Alluri V. Krishnaraju1 Amar A. Vishal2 Artatrana Mishra3 Golakoti Trimurtulu1 Kadainti VS Sarma4 Smriti K Raychaudhuri5 Siba P Raychaudhuri5 H 1. Laila Impex R D Center Jawahar Autonagar Vijayawada 520 007 India 2. Department of Orthopedics Alluri Sitarama Raju Academy of Medical Sciences ASRAM National Highway 5 Eluru 534 002 India 3. Department of Internal Medicine Alluri Sitarama Raju Academy of Medical Sciences ASRAM National High way 5 Eluru 534 002 India 4. Department of Statistics Prakasam Road SV University Tirupati 517 592 India 5. Department of Medicine Division of Rheumatology Allergy and Immunology School of Medicine U C Davis and VA Medical Center Sacramento Hospital Way Mather California 95655 USA H Corresponding author Siba P Raychaudhuri sraychaudhuri@ucdavis.edu Received 2010.09.01 Accepted 2010.10.15 Published 2010.11.01 Abstract Aflapin is a novel synergistic composition derived from Boswellia serrata gum resin Indian Patent Application No. 2229 CHE 2008 . Aflapin is significantly better as an anti-inflammatory agent compared to the Boswellia extracts presently available in the market. A 90-day double-blind randomized placebo-controlled study was conducted to evaluate the comparative efficacy and tolerability of 5-Loxin and Aflapin in the treatment of osteoarthritis OA of the knee Clinical trial registration number ISRCTN80793440 . Sixty OA subjects were included in the study. The subjects received either 100 mg n 20 of 5-Loxin or 100 mg n 20 of Aflapin or a placebo n 20 daily for 90 days. Each patient was evaluated for pain and physical functions by using the standard tools visual analog scale Lequesne s Functional .