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Báo cáo y học: "Treat Ankylosing Spondylitis with Methazolamide"

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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Treat Ankylosing Spondylitis with Methazolamide. | Int. J. Med. Sci. 2011 8 413 o IVYSPRING KiBjttTOJMRU L . International Journal of Medical Sciences 2011 8 5 413-419 Short Research Communication Treat Ankylosing Spondylitis with Methazolamide Xiaotian Chang1 x Xinfeng Yan2 Yunzhong Zhang3 1. National Laboratory for Bio-Drugs of Ministry of Health Provincial Laboratory for Modern Medicine and Technology of Shandong Research Center for Medicinal Biotechnology of Shandong Academy of Medical Sciences. Jingshi road 18877 Jinan Shandong 250062 P. R. China. 2. Orthopedic Surgery Center of Shandong Qianfoshan Hospital Jinan Shandong P. R. China. 3. Department of Rheumatic disease Occupational Disease Prevention Hospital of Shandong Jinan Shandong P. R. China. x Corresponding author Xiaotian Chang Mail address Jingshi Road 18877 Jinan Shandong 250062. P. R. China. E-mail changxt@126.com Tel 86-531-82919606 Fax 86-531-82951586 Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License http creativecommons.org licenses by-nc-nd 3.0 . Reproduction is permitted for personal noncommercial use provided that the article is in whole unmodified and properly cited. Received 2011.03.07 Accepted 2011.06.16 Published 2011.07.01 Abstract Background Increased bone resorption and new bone information are two characteristics of ankylosing spondylitis AS . Much evidence has shown that carbonic anhydrase inhibitors can restrain bone resorption. We had detected increased expression of carbonic anhydrase I CA1 in synovium of patients with AS. This study aimed to evaluate the effectiveness and safety of methazolamide an anti-carbonic anhydrase drug for treating patients with AS. Methods Two patients called as S and L were diagnosed with active AS based on BASDAI and BASFI assessments radiographic data and other clinical indices. They took methazolamide tablets at a dose of 25 mg twice every day. Results Patient S s BASDAI score fell from 5.4 to 4.4 while patient L s BASDAI fell

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Báo cáo y học: "Treat Ankylosing Spondylitis with Methazolamide"

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