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Báo cáo y học: "Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsivenes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsiveness. | ORIGINAL ARTICLE Bronchodilator Response in Patients with Persistent Allergic Asthma Could Not Predict Airway Hyperresponsiveness Bojana B. Petanjek MD Sanja P. Grle MD Dubravka Pelicaric MD and Dubravka Vrankovic MD Anticholinergics or specific antimuscarinic agents by inhibition of muscarinic receptors cause bronchodilatation which might correlate with activation of these receptors by the muscarinic agonist methacholine. The aim of this study was to determine whether a positive bronchodilator response to the anticholinergic ipratropium bromide could predict airway hyperresponsiveness in patients with persistent allergic asthma. The study comprised 40 patients with mild and moderate persistent allergic asthma. Diagnosis was established by clinical and functional follow-up skin-prick test spirometry bronchodilator tests with salbutamol and ipratropium bromide and methacholine challenge testing . The bronchodilator response was positive to both bronchodilator drugs in all patients. After salbutamol inhalation forced expiratory volume in 1 second FEV1 increased by 18.39 6.18 p .01 whereas after ipratropium bromide FEV1 increased by 19.14 6.74 p .01. The mean value of FEV1 decreased by 25.75 5.16 p .01 after methacholine PC20 FEV1 provocative concentration of methacholine that results in a 20 fall in FEV1 from 0.026 to 1.914 mg mL . Using linear regression between methacholine challenge testing and bronchodilator response to salbutamol a positive weak and stastistically significant correlation for FEV1 was found p .05 . Correlations between methacholine challenge testing and the bronchodilator response to ipratropium bromide were positive and weak but not statistically significant. The positive bronchodilator response to ipratropium bromide could not predict airway hyperresponsiveness. Key words airway hyperresponsiveness allergic asthma bronchodilator response ipratropium bromide methacholine challenge testing salbutamol Airway hyperresponsiveness in asthma is .