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Báo cáo y học: "The role of Probiotics in allergic diseases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The role of Probiotics in allergic diseases. | Allergy Asthma Clinical Immunology Review The role of Probiotics in allergic diseases Sonia Michail BioMed Central Open Access Address Department of Gastroenterology and Nutrition Wright State University Boonshoft School of Medicine Dayton Children s Medical Center Dayton Ohio 45404 USA Email Sonia Michail - sonia.michail@wright.edu Published 22 October 2009 Received I October 2009 Allergy Asthma Clinical Immunology 2009 5 5 doi 10.1186 1710-1492-5-5 Accepted 22 October 2009 This article is available from http www.aacijournal.com content 5 1 5 2009 Michail licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Allergic disorders are very common in the pediatric age group. While the exact etiology is unclear evidence is mounting to incriminate environmental factors and an aberrant gut microbiota with a shift of the Th1 Th2 balance towards a Th2 response. Probiotics have been shown to modulate the immune system back to a ThI response. Several in vitro studies suggest a role for probiotics in treating allergic disorders. Human trials demonstrate a limited benefit for the use of probiotics in atopic dermatitis in a preventive as well as a therapeutic capacity. Data supporting their use in allergic rhinitis are less robust. Currently there is no role for probiotic therapy in the treatment of bronchial asthma. Future studies will be critical in determining the exact role of probiotics in allergic disorders. Introduction Currently an estimated 20 of the population worldwide is suffering from some form of allergic disorder with a prevalence that continues to rise 1 . For example the prevalence of childhood asthma in the USA increased by 50 from 1980 to 2000 2 . Atopic diseases involve Th2 responses to allergens 3 . These clinical