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Báo cáo y học: "Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma. | Rousseau et al. Allergy Asthma Clinical Immunology 2011 7 8 http www.aacijournal.eom content 7 1 8 ALLERGY ASTHMA CLINICAL IMMUNOLOGY RESEARCH Open Access Comparative responses to nasal allergen challenge in allergic rhinitic subjects with or without asthma Marie-Claire Rousseau1 Marie-Eve Boulay1 Loie Goronfolah2 Judah Denburg2 Paul Keith2 and Louis-Philippe Boulet1 Abstract Background Nasal allergen challenge NAC is useful to study the pathophysiology of rhinitis and multiple challenges may more adequately approximate natural exposure. Objective To determine the effect of 4 consecutive daily NAC on clinical and inflammatory parameters in rhinitics with or without asthma. Methods Rhinitic subjects were recruited 19 with mild asthma and 13 without asthma. Subjects underwent a control challenge normal saline followed by 4 consecutive daily NAC. Allergen challenge consisted of spraying the chosen allergen extract into each nostril until a positive nasal response occurred. Symptoms were recorded on a Likert scale and oral peak expiratory and nasal peak inspiratory flows allowed assessment of a nasal blockage index NBI for a period of 7 hours. Induced sputum and nasal lavage were performed on control day and after 1 and 4 days of NAC. Results Compared with the control day there was a significant increase in symptom scores and NBI 10 minutes after each last daily NAC in both groups p 0.05 . Symptom scores and NBI were similar for the 2 groups except for nasal obstruction and rhinorrhea which were more marked in subjects with asthma and rhinitis respectively. Nasal lavage eosinophils were increased after 4 days of challenges in both groups but there was no change in sputum eosinophils. No cumulative effect or any late response were observed in any of the groups over the challenge period. Conclusion Multiple NAC may be a useful tool to study the pathophysiology of allergic rhinitis or its relationships with asthma. Trial registration ClinicalTrials.gov NCT01286129 .