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Báo cáo y học: "Anhedonia in schizophrenia and major depression: state or trait"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Anhedonia in schizophrenia and major depression: state or trait? | BioMed Central Annals of General Psychiatry Primary research Anhedonia in schizophrenia and major depression state or trait Lorenzo Pelizza and Alberto Ferrari Open Access Address Guastalla Psychiatric Service Reggio Emilia Mental Health Department Reggio Emilia Italy Email Lorenzo Pelizza - anolino@yahoo.it Alberto Ferrari - alberto.ferrari@ausl.re.it Corresponding author Published 8 October 2009 Received 16 March 2009 Annals of General Psychiatry 2009 8 22 doi l0.ll86 l744-859X-8-22 Accepted 8 October 2009 This article is available from http www.annals-general-psychiatry.com content 8 1 22 2009 Pelizza and Ferrari licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In schizophrenia and major depressive disorder anhedonia a loss of capacity to feel pleasure had differently been considered as a premorbid personological trait or as a main symptom of their clinical picture. The aims of this study were to examine the pathological features of anhedonia in schizophrenic and depressed patients and to investigate its clinical relations with general psychopathology negative positive and depressive dimensions . Methods A total of 145 patients 80 schizophrenics and 65 depressed subjects were assessed using the Physical Anhedonia Scale and the Social Anhedonia Scale PAS and SAS respectively the Scales for the Assessment of Positive and Negative Symptoms SAPS and SANS respectively the Calgary Depression Scale for Schizophrenics CDSS and the Hamilton Depression Rating Scale HDRS . The statistical analysis was performed in two steps. First the schizophrenic and depressed samples were dichotomised into anhedonic and normal hedonic subgroups according to the double PAS SAS cut-off and were compared on the general .