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Báo cáo y học: "Osteoclast-independent bone resorption by fibroblast-like cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Osteoclast-independent bone resorption by fibroblast-like cells. | Available online http arthritis-research.eom content 5 3 R163 Research article Open Access Osteoclast-independent bone resorption by fibroblast-like cells Thomas Pap1 2 Anja Claus3 Susumu Ohtsu2 Klaus M Hummel3 Peter Schwartz4 Susanne Drynda1 Géza Pap5 Andreas Machner5 Bernhard Stein6 Michael George6 Renate E Gay2 Wolfram Neumann5 Steffen Gay2 and Wilhelm K Aicher7 Division of Experimental Rheumatology Otto-von-Guericke University Magdeburg Germany 2Center of Experimental Rheumatology Department of Rheumatology University Hospital Zurich Switzerland 3Division of Nephrology and Rheumatology Georg-August-University Gottingen Germany 4Center of Anatomy Georg-August-University Gottingen Germany 5Clinic of Orthopedic Surgery Otto-von-Guericke-University Magdeburg Germany institute for Applied Physics Ludwig-Maximilians-University Munich Germany 7Research Laboratory Clinic of Orthopedic Surgery Tuebingen Germany Corresponding author Thomas Pap e-mail thomas.pap@medizin.uni-magdeburg.de Received 13 Sep 2002 Revisions requested 21 Oct 2002 Revisions received 14 Jan 2003 Accepted 25 Feb 2003 Published 26 Mar 2003 Arthritis Res Ther 2003 5 R163-R173 DOI 10.1186 ar752 2003 Pap et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract To date mesenchymal cells have only been associated with bone resorption indirectly and it has been hypothesized that the degradation of bone is associated exclusively with specific functions of osteoclasts. Here we show in aseptic prosthesis loosening that aggressive fibroblasts at the bone surface actively contribute to bone resorption and that this is independent of osteoclasts. In two separate models a severe combined immunodeficient mouse coimplantation model and a dentin pit formation assay these cells produce .