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Báo cáo y học: "The expansion of CD4+CD28– T cells in patients with rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The expansion of CD4+CD28– T cells in patients with rheumatoid arthritis. | Arthritis Research Therapy Vol 5 No 4 Pawlik et al. Research article Open Access The expansion of CD4 CD28- T cells in patients with rheumatoid arthritis Andrzej Pawlik1 Lidia Ostanek2 Iwona Brzosko2 Marek Brzosko2 Marek Masiuk3 Boguslaw Machalinski3 Barbara Gawronska-Szklarz1 1 Department of Pharmacokinetics and Therapeutic Drug Monitoring Pomeranian University of Medicine Szczecin Poland 2Department of Rheumatology Pomeranian University of Medicine Szczecin Poland 3Department of Pathology Pomeranian University of Medicine Szczecin Poland Corresponding author Andrzej Pawlik e mail pawand@poczta. onet.pl Received 20 Dec 2002 Revisions requested 5 Feb 2003 Revisions received 26 Feb 2003 Accepted 8 Apr 2003 Published 1 4 May 2003 Arthritis Res Ther 2003 5 R210-R213 DOI 10.1186 ar766 2003 Pawlik et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Clonal expansion of CD4 CD28- T cells is a characteristic finding in patients with rheumatoid arthritis RA . Expanded CD4 clonotypes are present in the peripheral blood infiltrate into the joints and persist for years. CD4 CD28- T cells are oligoclonal lymphocytes that are rare in healthy individuals but are found in high percentages in patients with chronic inflammatory diseases. The size of the peripheral blood CD4 CD28- T-cell compartment was determined in 42 patients with RA and 24 healthy subjects by two-color FACS analysis. The frequency of CD4 CD28- T cells was significantly higher in RA patients than in healthy subjects. Additionally the number of these cells was significantly higher in patients with extra-articular manifestations and advanced joint destruction than in patients with limited joint manifestations. The results suggest that the frequency of CD4 CD28- T cells may be a marker