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Báo cáo y học: "IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis κ synovial fibroblasts via NF-κB- and PI3-kinase/Akt-dependent pathways. | Arthritis Research Therapy Vol 6 No 2 Hwang et al. Research article Open Access IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kB- and PI3-kinase Akt-dependent pathways Sue-Yun Hwang1 Ju-Young Kim1 Kyoung-Woon Kim1 Mi-Kyung Park1 Youngmee Moon1 Wan-Uk Kim2 and Ho-Youn Kim1 2 Rheumatism Research Center Catholic Institutes of Medical Science The Catholic University of Korea Seoul Korea 2Center for Rheumatic Diseases Kangnam St Mary s Hospital The Catholic University of Korea Medical School Seoul Korea Correspondence Sue-Yun Hwang e-mail dutuya@cmc.cuk.ac.kr Received 22 Sep 2003 Revisions requested 23 Oct 2003 Revisions received 2 Nov 2003 Accepted 4 Dec 2003 Published 21 Jan 2004 Arthritis Res Ther 2004 6 R120-R128 DOI 10.1186 ar1038 2004 Hwang et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Recent studies of the pathogenesis of rheumatoid arthritis RA have revealed that both synovial fibroblasts and T cells participate in the perpetuation of joint inflammation as dynamic partners in a mutual activation feedback via secretion of cytokines and chemokines that stimulate each other. In this study we investigated the role of IL-17 a major Th1 cytokine produced by activated T cells in the activation of RA synovial fibroblasts. Transcripts of IL-17R IL-17 receptor and IL-17RB IL-17 receptor B were present in fibroblast-like synoviocytes FLS of RA patients. IL-17R responded with increased expression upon in vitro stimulation with IL-17 while the level of IL-17RB did not change. IL-17 enhanced the production of IL-6 and IL-8 in FLS as previously shown but did not affect the synthesis of IL-15. IL-17 appears to be a stronger inducer of IL-6 and IL-8 than IL-15 and even exerted activation .