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Báo cáo y học: "Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement. | Available online http arthritis-research.eom content 6 2 R137 Research article Open Access Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement Michele Bombardieri Cristiano Alessandri Giancarlo Labbadia Cristina lannuccelli Francesco Carlucci Valeria Riccieri Vincenzo Paoletti and Guido Valesini Cattedra di Reumatologia Dipartimento di Clinica e Terapia Medica Applicata - Università degli Studi di Roma La Sapienza Roma Italy These authors contributed equally in this study. Corresponding author Guido Valesini e-mail guido.valesini@uniroma1.it Received 12 Dec 2003 Accepted 13 Jan 2004 Published 29 Jan 2004 Arthritis Res Ther 2004 6 R137-R141 DOI 10.1186 ar1041 2004 Bombardieri et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract This study was performed to assess the utility of anti-eyelie citrullinated peptide anti-CCP antibodies in distinguishing between patients with rheumatoid arthritis RA and patients with polyarticular involvement associated with chronic hepatitis C virus HCV infection. Serum anti-CCP antibodies and rheumatoid factor RF were evaluated in 30 patients with RA 8 patients with chronic HCV infection and associated articular involvement and 31 patients with chronic HCV infection without any joint involvement. In addition we retrospectively analysed sera collected at the time of first visit in 10 patients originally presenting with symmetric polyarthritis and HCV and subsequently developing well-established RA. Anti-CCP antibodies and RF were detected by commercial second-generation anti-CCP2 enzyme-linked immunosorbent assay and immunonephelometry respectively. Anti-CCP antibodies .