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Báo cáo y học: "Cortisol and hypothalamic–pituitary–gonadal axis hormones in follicular-phase women with fibromyalgia and chronic fatigue syndrome and effect of depressive symptoms on these hormones"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cortisol and hypothalamic–pituitary–gonadal axis hormones in follicular-phase women with fibromyalgia and chronic fatigue syndrome and effect of depressive symptoms on these hormones. | Arthritis Research Therapy Vol 6 No 3 Gur et al. Research article Open Access Cortisol and hypothalamic-pituitary-gonadal axis hormones in follicular-phase women with fibromyalgia and chronic fatigue syndrome and effect of depressive symptoms on these hormones Ali Gur1 Remzi Cevik1 Kemal Nas1 Leyla Colpan2 and Serdar Sarac3 Department of Physical Medicine and Rehabilitation School of Medicine Dicle University DiyarbakIr Turkey 2Department of Biochemistry School of Medicine Dicle University Diyarbakir Turkey 3Department of Physical Medicine and Rehabilitation Kartal State Hospital Istanbul Turkey Corresponding author Ali Gur e-mail alig@dicle.edu.tr Received 20 Aug 2003 Revisions requested 26 Sep 2003 Revisions received 6 Feb 2004 Accepted 19 Feb 2004 Published 15 Mar 2004 Arthritis Res Ther 2004 6 R232-R238 DOI 10.1186 ar1163 2004 Gur et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract We investigated abnormalities of the hypothalamic-pituitary-gonadal axis and cortisol concentrations in women with fibromyalgia and chronic fatigue syndrome CFS who were in the follicular phase of their menstrual cycle and whether their scores for depressive symptoms were related to levels of these hormones. A total of 1 76 subjects participated - 46 healthy volunteers 68 patients with fibromyalgia and 62 patients with CFS. We examined concentrations of follicle-stimulating hormone luteinizing hormone LH estradiol progesterone prolactin and cortisol. Depressive symptoms were assessed using the Beck Depression Inventory BDI . Cortisol levels were significantly lower in patients with fibromyalgia or CFS than in healthy controls P 0.05 there were no significant differences in other hormone levels between the three groups. Fibromyalgia patients with high BDI scores had significantly lower cortisol .