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Báo cáo y học: "Lymphopenia and autoimmune diseases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Lymphopenia and autoimmune diseases. | Arthritis Research Therapy Vol 6 No 4 Schulze-Koops Viewpoint Lymphopenia and autoimmune diseases Hendrik Schulze-Koops Nikolaus Fiebiger Center for Molecular Medicine Clinical Research Group III and Department of Internal Medicine III and Institute for Clinical Immunology University of Erlangen-Nuremberg Glueckstrasse 6 91054 Erlangen Germany Corresponding author Hendrik Schulze-Koops Schulze-Koops@med3.imed.uni-erlangen.de Received 24 May 2004 Accepted 8 Jun 2004 Published 22 Jun 2004 Arthritis Res Ther 2004 6 178-180 DOI 10.1186 ar1208 2004 BioMed Central Ltd Autoimmunity induced by lymphopenia More than 30 years ago the occurrence of spontaneous autoimmune thyroiditis was observed in rodents that were made severely T-cell lymphopenic by neonatal thymectomy or by thymectomy at week five after birth together with concomitant low dose irradiation 1 2 . Following these reports numerous studies have shown that manipulations that generate functional T-cell lymphopenia result in the development of a variety of organ-specific autoimmune diseases in animal models reviewed in 3 . Impressive examples of such manipulations include IL-2 knockout mice that develop prominent autoimmune colitis 4 T-cell receptor-alpha chain deficient mice that develop inflammatory bowel disease associated with an array of autoantibodies 5 6 T-cell receptor-a chain transgenic mice 7 neonatal application of cytotoxic intervention protocols such as cyclosporine A 8 total lymphoid irradiation 9 or thymectomy 10 and lymphotoxic treatment of adult animals 11 . It was subsequently found that adoptive transfer of T cells into congenic immunocompromised hosts initiated the spontaneous development of aggressive inflammatory autoimmunity in recipients 12 . Further studies revealed that the development of autoimmunity in hosts was critically dependent on both transfer of alpha beta CD4-positive T cells and T-cell deficiency in the recipients. Together these data indicate that lymphopenia promotes the .